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Core Drivers of Autoimmune Diseases
- Danuta Domurad
- Nov 28, 2025
- 1 min read
Core Drivers of Autoimmune Diseases
1. Immune Tolerance Breakdown (Not Genes)
The immune system is designed to distinguish “self” from “non-self.”
Autoimmunity happens when this recognition system is disturbed—often by chronic inflammation, toxins, infections, or gut permeability.
2. Gut & Microbiome Dysregulation
Leaky gut: intestinal lining damage allows proteins, microbes, and toxins to enter the bloodstream.
The immune system responds aggressively → chronic mistaken attacks.
Dysbiosis (imbalanced gut flora) is almost universal in autoimmune patients.
3. Toxins & Environmental Stressors
Heavy metals (mercury, aluminum), pesticides, plastics (BPA), and mold toxins can confuse immune signaling.
The immune system, unable to fully clear these, starts reacting broadly—including to the body itself.
4. Infections & Molecular Mimicry
Some microbes resemble human proteins.
Example: Streptococcus bacteria and rheumatic fever; EBV (Epstein–Barr Virus) linked to lupus, MS, Hashimoto’s.
The immune system attacks the invader and healthy tissues that look “similar.”
5. Stress & Trauma
Emotional and physical trauma disrupt the hypothalamus–pituitary–adrenal (HPA) axis.
Chronic stress = cortisol imbalance → immune system becomes dysregulated.
In psychosomatic terms: self-attack reflects inner conflict, suppressed anger, or lack of self-acceptance.
6. Epigenetics
The real “switch”: environment and beliefs turn on or silence immune-related genes.
This explains why one sibling develops an autoimmune disease and another doesn’t—even with the same genes.
Truth in one line: Autoimmune disease is not the body “malfunctioning” by accident—it’s the body overwhelmed by environmental, microbial, toxic, and emotional stressors, losing its ability to maintain tolerance. Genetics sets a very small predisposition, but environment and consciousness write the actual story.
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